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Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na +, K +, Ca 2+, and/or Cl − to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
Ligand-gated ion channel. Ligand-gated ion channels (LGICs) are one type of ionotropic receptor or channel-linked receptor. They are a group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger (i.e., a ligand), [7] such as a neurotransmitter. [8]
Examples of such channels include the cation-permeable nicotinic acetylcholine receptors, ionotropic glutamate-gated receptors, acid-sensing ion channels (ASICs), [16] ATP-gated P2X receptors, and the anion-permeable γ-aminobutyric acid-gated GABA A receptor. Ion channels activated by second messengers may also be categorized in this group ...
The subunits of the nicotinic receptors belong to a multigene family (16 members in humans) and the assembly of combinations of subunits results in a large number of different receptors (for more information see the Ligand-Gated Ion Channel database). These receptors, with highly variable kinetic, electrophysiological and pharmacological ...
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .
Ion channels located on the surface membrane of the neuron allows for an influx of sodium ions and outward movement of potassium ions during an action potential. Selectively blocking these ion channels will decrease the likelihood of an action potential to occur. The drug riluzole is a neuroprotective drug that blocks sodium ion channels. Since ...
Ionotropic glutamate receptors (iGluRs) form the ion channel pore that activates when glutamate binds to the receptor. Metabotropic glutamate receptors (mGluRs) affect the cell through a signal transduction cascade, and they may be primarily activating (mGlur 1/5) or primarily inhibitory (mGlur 2/3 and mGlur 4/6/7/8). Ionotropic receptors tend ...
Fast-responding GABA receptors are members of a family of Cys-loop ligand-gated ion channels. [7] [8] [9] Members of this superfamily, which includes nicotinic acetylcholine receptors, GABA A receptors, glycine and 5-HT 3 receptors, possess a characteristic loop formed by a disulfide bond between two cysteine residues. [10]