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Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. [ 5 ] [ 6 ] TfR1 is required for iron import from transferrin into cells by endocytosis .
TfR2 binds to transferrin with a 25-30 fold lower affinity than TfR1. [3] [4] Although TfR1 mediated iron uptake is the major pathway for iron acquisition by most cells and especially developing erythrocytes, several studies have indicated that the uptake mechanism varies depending upon the cell type. It is also reported that Tf uptake exists ...
Each monomer consists of three domains: the protease, the helical, and the apical domains. The shape of a transferrin receptor resembles a butterfly based on the intersection of three clearly shaped domains. [18] Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2).
Conventional iron uptake pathways, such as those using the transferrin receptor 1 (TfR1), often prove insufficient to meet these elevated iron demands in cancer cells. As a result, various cytokines and growth factors trigger the upregulation of CD44, a surface molecule capable of internalizing iron bound to the hyaluronan complex. This ...
They are found in the cytoplasmic tails of non-catalytic tyrosine-phosphorylated receptors [7] such as the CD3 and ζ-chains of the T cell receptor complex, the CD79-alpha and -beta chains of the B cell receptor complex, and certain Fc receptors. [1] [7] The tyrosine residues within these motifs become phosphorylated by Src family kinases ...
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.
Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF 1, with the latter (CRF 1) now being the IUPHAR-recommended name. [4] In humans, CRF 1 is encoded by the CRHR1 gene at region 17q21.31, beside micrototubule-associated protein tau MAPT .
Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene. [5]TAAR1 is a primarily intracellular amine-activated G s-coupled and G q-coupled G protein-coupled receptor (GPCR) that is primarily expressed in several peripheral organs and cells (e.g., the stomach, small intestine, duodenum, and white blood cells ...