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Ruxolitinib (sold under the brand names Jakafi and Jakavi among others, and as Opzelura in cream form) is a medication used for the treatment of intermediate or high-risk myelofibrosis, [6] a type of myeloproliferative neoplasm that affects the bone marrow; [11] [12] polycythemia vera, when there has been an inadequate response to or intolerance of hydroxyurea; [6] [13] and steroid-refractory ...
The prescribing information for Jakafi now includes a new recommended starting dose of 5 mg twice daily of Jakafi for patients with baseline platelet counts between 50-100 x 10 9 /L (50,000 to ...
A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.
Jakafi is approved in the U.S. for treating acute GvHD and is considered a remedy for certain bone marrow and blood d FDA approves Incyte's treatment for chronic graft-versus-host disease Skip to ...
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).
Bulk material handling systems are typically composed of stationary machinery such as conveyor belts, screw conveyors, tubular drag conveyors, moving floors, toploaders, stackers, reclaimers, bucket elevators, truck dumpers, railcar dumpers or wagon tipplers, shiploaders, hoppers and diverters and various mobile equipment such as loaders ...
The Sd.Kfz. 250 (German: Sonderkraftfahrzeug 250; 'special motor vehicle') was a light armoured half-track, very similar in appearance to the larger Hanomag-designed Sd.Kfz. 251, and built by the DEMAG firm, for use by Nazi Germany in World War II. Most variants were open-topped and had a single access door in the rear.
The engine was an air-cooled, two-stroke, two-cylinder unit originally displacing 250 cc, but later available in increased sizes of 300 cc and 400 cc. It had an electric pre-selective transmission built by Getrag and a manual clutch. The engine was behind the rear wheels. Suspension was independent all round using coil springs with swing axles.