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Manganese superoxide dismutase (MnSOD) is the principal antioxidant in mitochondria. Several enzymes activated by manganese contribute to the metabolism of carbohydrates, amino acids, and cholesterol. [2] A deficiency of manganese causes skeletal deformation in animals and inhibits the production of collagen in wound healing. [3]
The U.S. Institute of Medicine (IOM) sets tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient. In the case of copper the adult UL is set at 10 mg/day. [4] Copper gluconate is sold as a dietary supplement to provide copper. The typical dose is 2.0 mg copper per day.
Copper deficiency, or hypocupremia, is defined as insufficient copper to meet the body's needs, or as a serum copper level below the normal range. [1] Symptoms may include fatigue , decreased red blood cells , early greying of the hair, and neurological problems presenting as numbness , tingling, muscle weakness, and ataxia . [ 2 ]
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manganese deficiency / manganism: Copper: 0.9 10; 5 Required co-factor for cytochrome c oxidase: Liver, seafood, oysters, nuts, seeds; some: whole grains, legumes [29] copper deficiency / copper toxicity: Iodine: 0.150 1.1; 0.6 Required for the synthesis of thyroid hormones and to help enzymes in host defense
Copper deficiency is a major issue in global food production, resulting in losses in yield and reduced quality of output. Nitrogen fertilizers can worsen copper deficiency in agricultural soils. [citation needed] The world's two most important food crops, rice and wheat, are highly susceptible to copper deficiency.
Manganese deficiency in humans, which is rare, results in a number of medical problems. Many common vitamin and mineral supplement products fail to include manganese in their compositions. Relatively high dietary intake of other minerals such as iron, magnesium, and calcium may inhibit the proper intake of manganese.
Methylsulfonylmethane is marketed as a dietary supplement with medical claims ranging from anti-inflammatory effects for pain management, skin condition and aging treatments, and immune system modulation. [9] [10] [11] No medical uses for MSM have been approved and there is limited evidence to support most of the claims.
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