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The androgen backdoor pathways occur without the involvement of testosterone (T) and/or androstenedione (A4), which are part of the conventional, canonical (classic) [30] [31] [11] androgenic pathway. [15] In the canonical pathways of androgen biosynthesis, DHT is synthesized from T via 5α-reduction, so that 5α-reduction of T, a C
removed 11KT since it is not a significant product of the 11-oxy backdoor pathway: 17:21, 18 February 2024: 1,200 × 675 (365 KB) Boghog: Reverted to version as of 11:25, 17 February 2024 (UTC) 14:08, 18 February 2024: 1,200 × 675 (371 KB) Boghog: Added the 11-oxy backdoor pathway is also important in healthy females: 11:25, 17 February 2024: ...
English: Will update with all enzyme names once diagram is checked for accuracy. Date: 5 February 2021: Source: Own work: Author: ... The androgen backdoor pathway ...
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone [27] [28] [29] CAH is a genetic disorder characterized by impaired production of cortisol in the adrenal glands. [1] [4] Production of cortisol begins at week 8 of fetal ...
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone. [ 7 ] [ 8 ] [ 9 ] 5α-Pregnan-17α-ol-3,20-dione (17-OH-DHP) is a progestogen , i.e., it binds to the progesterone receptors .
As with the conventional pathway of DHT synthesis, the backdoor pathway similarly requires 5α-reductase. [63] Whereas 5α-reduction is the last transformation in the classical androgen pathway, it is the first step in the backdoor pathway. [17]
In 21-hydroxylase deficiency, especially in mild cases (LOCAH), the androgen "backdoor" pathway [18] may be the reason of androgen excess. [54] This backdoor pathway is not always considered in the clinical evaluation of patients with hyperandrogenism conditions such as LOCAH and may be a source of diagnostic pitfalls and confusion. [55]
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