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Paroxysmal extreme pain disorder originally named familial rectal pain syndrome, is a rare disorder whose most notable features are pain in the mandibular, ocular and rectal areas as well as flushing. PEPD often first manifests at the beginning of life, perhaps even in utero, with symptoms persisting throughout
Erythropoietic protoporphyria (or commonly called EPP) is a form of porphyria, which varies in severity and can be very painful.It arises from a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the red blood cells (erythrocytes), plasma, skin, and liver. [2]
The disease was characterized by burning pain in the toes and soles of the feet, accompanied by foot redness, congestion, and edema; a few patients had fever, palpitations, headache, and joint pain. 60.6% of patients had a common cold before the onset of erythromelalgia and 91.2% had pharyngitis.
The diagnosis should be made only after excluding other possible causes of similar symptoms such as tuberculosis. [6] Sarcoidosis may resolve without any treatment within a few years. [2] [5] However, some people may have long-term or severe disease. [5] Some symptoms may be improved with the use of anti-inflammatory drugs such as ibuprofen. [8]
NP in adults was first described in the 1940s, whereas in children it was reported later in 1994. [3] Necrotizing pneumonia is an ancient disease which was once a leading cause of death in both adults and children. [9] Its clinical features were presumably first outlined by Hippocrates. [9]
The causes of pelvic floor dysfunction aren’t well understood. Experts know that weakened muscles and connective tissue in the pelvis can contribute to it, as can injuries to the pelvis.
PDP occurs more frequently in men than in women (ratio around 7:1). [1] [4] Moreover, men suffer from more severe symptoms (see table 1). [1] African American people are affected to a higher extent. [5] Table 1. Distribution of different forms of PDP among 201 reported affected men and women (167 men and 34 women). [1]
A progressively severe sore throat on one side and pain during swallowing (odynophagia) usually are the earliest symptoms. As the abscess develops, persistent pain in the peritonsillar area, fever , a general sense of feeling unwell , headache, and a distortion of vowels informally known as "hot potato voice" may appear.