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Tetanus immunoglobulin (TIG), [1] also called tetanus antibodies or tetanus antitoxin. [46] It can be given as intravenous therapy or by intramuscular injection. Antibiotic therapy to reduce toxin production. Metronidazole intravenous (IV) is a preferred treatment. [48] Benzodiazepines can be used to control muscle spasms.
[6] [1] Tetanospasmin ("tetanus toxin") is a potent toxin with an estimated lethal dose less than 2.5 nanograms per kilogram of body weight, and is responsible for the symptoms of tetanus. [6] [1] Tetanospasmin spreads via the lymphatic system and bloodstream throughout the body, where it is taken up into various parts of the nervous system. [6]
1924 – First inactive vaccine for tetanus (tetanus toxoid, TT) by Gaston Ramon, C. Zoeller and P. Descombey; 1926 – First vaccine for pertussis (whooping cough) by Leila Denmark; 1932 – First vaccine for yellow fever by Max Theiler and Jean Laigret; 1937 – First vaccine for typhus by Rudolf Weigl, Ludwik Fleck and Hans Zinsser
Tetanus antiserum was developed in 1890, with its protective effects lasting a few weeks. [9] [10] The tetanus toxoid vaccine was developed in 1924, and came into common use for soldiers in World War II. [2] [11] Its use resulted in a 95% decrease in the rate of tetanus. [2] It is on the World Health Organization's List of Essential Medicines. [12]
Kitasato's discoveries on tetanus and von Behring's work on diphtheria lead to the field of serotherapy, which has benefitted many worldwide. [4] After returning to Japan in 1891, he founded the Institute for Study of Infectious Diseases with the assistance of Fukuzawa Yukichi. One of his early assistants was August von Wassermann.
An early start of Hepatitis B vaccine reduces the chance of being infected and becoming a carrier. [8] Prevents liver cirrhosis and liver cancer which are more likely to develop if infected with Hepatitis B early in life. [9] [10] About 9,000 died of complications of Hepatitis B. 10% of Filipinos have Hepatitis B infection [11] Measles Vaccine ...
We look at what's really happening with the program supporting 70 million Americans.
Neonatal tetanus (trismus nascentium) is a form of generalised tetanus that occurs in newborns. ... deaths from neonatal tetanus was 787,000 in the early 1980s. [2]