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Antiglucocorticoid drugs are a class of medications that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. [1] They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome. [2]
The most common adverse effects include abdominal pain, feeling tired, and vaginal bleeding. [8] Serious side effects may include heavy vaginal bleeding, bacterial infection, and, if pregnant, birth defects. [8] When used, appropriate follow-up care needs to be available. [8] [14] Mifepristone is primarily an antiprogestogen. [8]
Mifepristone is used in more than half of all abortions in the US. The drug was first approved for use by the US Food and Drug Administration in most cases up to 10 weeks of pregnancy in 2000.
Mifepristone was approved for use 23 years ago, and can be taken up to 10 weeks of pregancy, when the vast majority of abortions are performed. The drug is used similarly in dozens of countries.
A majority of Supreme Court justices appeared skeptical Tuesday of the idea of a nationwide ban or new limits on mifepristone, the primary drug used for medication abortions.
Hydroxyprogesterone caproate is generally well tolerated and produces few side effects. [1] Injection site reactions such as pain and swelling are the most common side effect of hydroxyprogesterone caproate. [1] The medication may increase the risk of gestational diabetes when used in pregnant women.
The U.S. Supreme Court will take up a case Tuesday that could impact how women get access to mifepristone, one of the two pills used in the most common type of abortion in the nation.
Sustained-release dosage forms are dosage forms designed to release (liberate) a drug at a predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects. This can be achieved through a variety of formulations, including liposomes and drug-polymer conjugates (an example being ...
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