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A clinical trial testing sertraline (Zoloft) for depression of Alzheimer disease, launched by the NIMH in 2004, was due to be completed in the summer of 2009. [9] [needs update] Sertraline, as per the latest studies has been found to be ineffective in improving cognitive outcomes in patients with Alzheimer's disease. [10]
The most common type of mixed dementia is Alzheimer's disease and vascular dementia. [93] This particular type of mixed dementia's main onsets are a mixture of old age, high blood pressure, and damage to blood vessels in the brain. [15] Diagnosis of mixed dementia can be difficult, as often only one type will predominate.
The disease was first described as a distinctive disease by Emil Kraepelin after suppressing some of the clinical (delusions and hallucinations) and pathological features (arteriosclerotic changes) contained in the original report of Auguste D. [248] He included Alzheimer's disease, also named presenile dementia by Kraepelin, as a subtype of ...
Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. [14] It is the most common neurodegenerative disease. [1]
“That finding is not surprising to me, because there are early life, midlife and late-life risk factors for dementia. (For) Alzheimer’s disease, for example, pathology starts in the brain ...
The American Journal of Alzheimer's Disease & Other Dementias is aimed primarily at professionals on the frontline of Alzheimer's care, dementia and clinical depression and other specialists who manage patients with dementias and their families. The journal aims to provide practical information about medical, psychiatric and nursing issues.
Pre-dementia or early-stage dementia (stages 1, 2, and 3). In this initial phase, a person can still live independently and may not exhibit obvious memory loss or have any difficulty completing ...
In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.
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