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Anisocoria is a common condition, defined by a diameter difference of 0.4 mm or more between the sizes of the pupils of the eyes. [2] Anisocoria has various causes: [3] Physiological anisocoria: About 20% of the population has a slight
The main characteristic that distinguishes physiological anisocoria is an increase of pupil size with lower light or reduced illumination, such that the pupils differ in size between the two eyes. At any given eye examination, up to 41% of healthy patients can show an anisocoria of 0.4 mm or more at one time or another.
Anisocoria caused by tropicamide instilled into the subject's right eye only. Tropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia [7] when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina.
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Some cancer chemotherapy drugs, including camptothecin derivatives; Mirtazapine, a noradrenergic and specific serotonergic antidepressant ; Some MAO inhibitors; Pilocarpine eye drops and all other parasympathomimetics; In some rare cases, when exposed to mustard gas; Organophosphates
Mechanical anisocoria refers to anisocoria, a common eye condition in which the two pupils differ in size, that is the result of damage to the iris dilator muscle, which may be caused by trauma, angle-closure glaucoma, surgery such as cataract removal, or uveitis (inflammation of the eye).