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In contrast, dominant monkeys experienced a decrease in cocaine self-administration and a rightward shift in the dose-response curve. Brain glucose metabolism measurements revealed differences between dominant and subordinate monkeys, shedding light on the underlying mechanisms of these opposing behavioral effects. Dominant monkeys showed ...
Cocaine is a non-selective, competitive inhibitor of monoamine transporters, sharing a similar mechanism with that of methylphenidate. Cocaine interacts with DAT, SERT, and NET, although the behavioral and reinforcing effects of cocaine depend on its inhibition of DAT and the increase in extracellular dopamine. [1]
The effects of cocaine are similar to those of amphetamines, though cocaine tends to have a shorter duration of effect. In high doses or with prolonged use, cocaine can result in a number of negative effects, including irritability, anxiety, exhaustion, total insomnia, and even psychotic symptomatology.
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [188] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
This suggests a positive neuromodulatory action of CART on the effects of psychostimulants in rats. [18] CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene is associated with alcoholism. [19] By inhibiting the rewarding effects of cocaine, CART has a potential use in treating cocaine ...
Different activities had varying effects on participants’ brain waves. Playing and walking with a dog increased the strength of the alpha-band oscillations, the authors found, which generally ...
Opiates stimulate dopamine neurons in the brain indirectly by inhibiting GABA release from modulatory interneurons that synapse onto the dopamine neurons. GABA is an inhibitory neurotransmitter that decreases the probability that the target neuron will send a subsequent signal.
The post Study Finds Dogs Associate Words With Objects appeared first on DogTime. A recent study has shed light on the cognitive abilities of dogs, demonstrating that they can associate specific ...