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Eplerenone is an antimineralocorticoid, or an antagonist of the mineralocorticoid receptor (MR). [21] Eplerenone is also known chemically as 9,11α-epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone and "was derived from spironolactone by the introduction of a 9α,11α-epoxy bridge and by substitution of the 17α-thoacetyl ...
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Dabing Street is a Czech comedy TV series. The plot is set in the summer of 2001 and describes what happens in a fictional dubbing company Studio ZERO after its owner dies. His widow takes over the company and tries to share the management of the studio with the employees.
Eplerenone, a steroidal antimineralocorticoid of the spirolactone group; Estriol triacetate, an estrogen medication and an estrogen ester
For people with hyperplasia of both glands, successful treatment is often achieved with spironolactone or eplerenone, drugs that block the aldosterone receptor. With its antiandrogen effect, spironolactone drug therapy may have a range of side effects in males and females, including gynecomastia and irregular menses.
Esaxerenone (INN Tooltip International Nonproprietary Name) (brand name Minnebro; developmental code names CS-3150, XL-550) is a nonsteroidal antimineralocorticoid which was discovered by Exelixis and developed by Daiichi Sankyo Company and is approved in Japan for the treatment of hypertension.
Logo. iVysílání is a streaming platform operated by Czech Television. [1] It provides viewers with access to a wide range of television programmes produced by Czech Television, as well as films and shows licensed to the network.
Paramount Network (originally Prima Comedy Central) is a Czech television channel operated by the American media concern Paramount International Media Networks (in the Czech Republic it also broadcasts, for example, MTV, VH1, Nickelodeon or Comedy Central Extra).