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Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . [ 5 ]
Myelin's best known function is to increase the rate at which information, encoded as electrical charges, passes along the axon's length. Myelin achieves this by eliciting saltatory conduction. [1] Saltatory conduction refers to the fact that electrical impulses 'jump' along the axon, over long myelin sheaths, from one node of Ranvier to the next.
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A nerve tissue protein is a biological molecule related to the function and maintenance of normal nervous tissue. [1] An example would include, for example, the generation of myelin which insulates and protects nerves. These are typically calcium-binding proteins.
The insulation must be proportional to the diameter of the fibre inside. The optimal ratio of axon diameter divided by the total fiber diameter (which includes the myelin) is 0.6. [24] Oligodendrocytes in rat cerebellum stained with antibody to myelin basic protein in red and for DNA in blue. Two oligodendrocyte cell bodies are clearly visible ...
The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the efficiency of axonal impulse conduction. [ 2 ] In humans, point mutations in PLP are the cause of Pelizaeus–Merzbacher disease (PMD), a neurologic disorder of myelin metabolism.
Myelinogenesis is the formation and development of myelin sheaths in the nervous system, typically initiated in late prenatal neurodevelopment and continuing throughout postnatal development. [1] Myelinogenesis continues throughout the lifespan to support learning and memory via neural circuit plasticity as well as remyelination following ...
18857 Ensembl ENSG00000147588 ENSMUSG00000052468 UniProt P02689 P24526 RefSeq (mRNA) NM_002677 NM_001348381 NM_001030305 RefSeq (protein) NP_002668 NP_001335310 NP_001025476 Location (UCSC) Chr 8: 81.44 – 81.45 Mb Chr 3: 10.24 – 10.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene. Myelin protein P2 is a ...