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A 2020 review of 21 studies on metformin and weight loss found that metformin results in a statistically significant reduction of BMI in individuals with obesity, and otherwise moderately...
Those on metformin had an average 2.5-kg weight loss over time, while the lifestyle intervention group progressively regained weight, with a final average weight loss of 2.0 kg after 10 years of follow-up. 3
On average, weight loss after one year on the drug is only six pounds, according to past research. So while metformin is often given to people with high insulin levels who have difficulty...
The average weight loss in the group that received metformin was 5.8 kg (12.8 lbs) ±7 kg (± 15 lbs). Untreated controls gained 0.8 kg (1.8 lbs) ± 3.5 kg (± 7.7 lbs) on average. Patients with severe insulin resistance lost significantly more weight as compared to insulin sensitive patients.
In a long-term study involving over 3,000 people, the average weight loss for participants who took metformin was 5.5 pounds. About one-third of those who took metformin lost at least 5% of...
One review of studies found that, on average, metformin in adults over 60 resulted in about 4 pounds of weight loss compared with a placebo. Another study assessed metformin's effect on weight in 154 individuals with obesity who did not have diabetes.
Metformin has been linked to weight loss in people with diabetes due to a variety of factors, including improved blood sugar control and reduced hunger cues. Typical weight loss ranges from 4 to 7 pounds per year.
Patients randomized to metformin experienced a 2.1-kg weight loss on average. The extent of weight change was strongly associated with adherence, with highly adherent patients experiencing an average of a 3.5% reduction in body mass and low adherence associated with weight-neutral status in 2 years of follow-up [15 ••].
Over the total follow-up, average weight loss from baseline in the metformin treatment group, independent of adherence, was 2.0% (1.9 kg). Among those highly adherent to metformin, weight loss from baseline was 3.5% (3.1 kg).
We treated 154 consecutive patients with a body mass index ≥27 kg/m 2 in an outpatient setting over 6 months with metformin up to a dosage of 2 500 mg per day. Additionally, we included 45 untreated patients as controls. Patients were monitored for weight changes over 6 months.