Search results
Results from the WOW.Com Content Network
The two mouse ROCK isoforms, ROCK1 and ROCK2, have high homology.They have 65% amino acid sequences in common and 92% homology within their kinase domains. [1] [4]ROCKs are homologous to other metazoan kinases such as myotonic dystrophy kinase (), DMPK-related cell division control protein 42 ()-binding kinases (MRCK) and citron kinase.
Another example from South Wales is the Usk Inlier in Monmouthshire where Silurian age rocks are upfolded amidst Old Red Sandstone rocks of Devonian age. A similar outcrop pattern which results from movement on a thrust fault followed by erosion may be termed a window. Conversely an outlier is an area of younger rock surrounded by older rocks ...
In structural geology, a fold is a stack of originally planar surfaces, such as sedimentary strata, that are bent or curved ("folded") during permanent deformation. Folds in rocks vary in size from microscopic crinkles to mountain-sized folds. They occur as single isolated folds or in periodic sets (known as fold trains).
Global downhill folding (or one-state folding) is another scenario in which the protein folds in the absence of a free energy barrier under all conditions. In other words, there is a unimodal population distribution at all temperatures and denaturant concentrations, suggesting a continuous unfolding transition in which different ensembles of ...
Some proteins need the assistance of chaperone proteins to fold properly. It has been suggested that this disproves Anfinsen's dogma. However, the chaperones do not appear to affect the final state of the protein; they seem to work primarily by preventing aggregation of several protein molecules prior to the final folded state of the protein ...
A nucleation-condensation mechanism involving concomitant formation of short and long-range interactions combines features of both extreme models and thereby represents a unifying mechanism of protein folding. [3] During folding, proteins span a continuum of conformers starting from the denature and ending at the native state.
The influenza virus protein viral neuraminidase is a six-bladed beta-propeller protein whose active form is a tetramer. [11] It is one of two proteins present in the viral envelope and catalyzes the cleavage of sialic acid moieties from cell-membrane proteins to aid in the targeting of newly produced virions to previously uninfected cells. [12]
The use of rock has had a huge impact on the cultural and technological development of the human race. Rock has been used by humans and other hominids for at least 2.5 million years. [22] Lithic technology marks some of the oldest and continuously used technologies. The mining of rock for its metal content has been one of the most important ...