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The ultimate consequence of cytotoxic edema is the oncotic death of neurons. [1] The swelling of the individual cells of the brain is the main distinguishing characteristic of cytotoxic edema, as opposed to vasogenic edema, wherein the influx of fluid is typically seen in the interstitial space rather than within the cells themselves. [20]
Risk factors include being overweight or a recent increase in weight. [1] Tetracycline may also trigger the condition. [2] The diagnosis is based on symptoms and a high opening pressure found during a lumbar puncture with no specific cause found on a brain scan. [1] [2] Treatment includes a healthy diet, salt restriction, and exercise. [2]
Steroids such as Decadron may be required to treat swelling in the brain. Decadron can lead to weight gain and infection. Patients may also experience seizures, which need to be treated to avoid complications. For some patients there is a chance of a neurological breakdown; this can include, but is not limited to, confusion and memory loss. [5]
As well as this, it is common to incur an elevated blood protein level and a high volume of lymph cells within the cerebrospinal fluid, resulting in swelling and enlargement of the brain. The most characteristic signs and symptoms experienced by patients with cerebellar degeneration include: [2] [4] muscle weakness; an uncoordinated, staggering ...
The primary purpose of osmotherapy is to improve elasticity and decrease intracranial volume by removing free water, accumulated as a result of cerebral edema, from brain's extracellular and intracellular space into vascular compartment by creating an osmotic gradient between the blood and brain.
These factors cause the brain to swell with fluid, resulting in severe impairment. [15] If the swelling is untreated, it causes death by brain herniation. [4] The brain swelling is likely a result of vasogenic edema, the penetration of the blood–brain barrier by fluids. [16] This process has been observed in MRI studies.
Lee's death was officially ruled the result of cerebral edema — swelling of the brain. While a normal human brain is about 3 pounds, Lee's was reportedly closer to 3½ pounds.
The symptoms depend on the cause of the blockage, the person's age, and how much brain tissue has been damaged by the swelling. [11] Hydrocephalus ex vacuo is a condition in which there is ventriculomegaly due to loss of brain volume which then results in a subsequent increase in CSF. [19]