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2. Monoclonal B-cell lymphocytosis - Wikipedia

   en.wikipedia.org/wiki/Monoclonal_B-cell_lymphocy...

   Mantle cell lymphoma: The monoclonal B-cells in this aggressive lymphoma are CD5+ in most cases, CD10−, CD23−, CD43+, CD103−, complete Ig+, and express cyclin D1; these cells have translocations between chromosomes 11 and 14 in >95% of cases and in many cases overexpress the SOX11 transcription factor gene. [2]

3. Immunoglobulin light chain - Wikipedia

   en.wikipedia.org/wiki/Immunoglobulin_light_chain

   If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell ...

4. Germinal center B-cell like diffuse large B-cell lymphoma

   en.wikipedia.org/wiki/Germinal_center_B-cell...

   CD20. Approximately 95% of B-cell lymphomas express CD20, but CD20 is not critical for B-cell survival. Clonal B-cells spontaneously mutate the idiotypic region of their immunoglobulin. This high mutation rate makes them prone to the selection of B-cells lacking the CD20 antigen following treatment with CD20-targeting monoclonal antibodies.

5. B-cell lymphoma - Wikipedia

   en.wikipedia.org/wiki/B-cell_lymphoma

   The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph nodes . They develop more frequently in older adults and in immunocompromised individuals.

6. List of therapeutic monoclonal antibodies - Wikipedia

   en.wikipedia.org/wiki/List_of_therapeutic...

   B-cell activating factor (BAFF) B-cell cancers Tacatuzumab tetraxetan: AFP-Cide: mab: humanized: alpha-fetoprotein: cancer Tadocizumab [101] Fab: humanized: integrin α IIb β 3: percutaneous coronary intervention: Tafasitamab [47] Monjuvi: mab: humanized (from mouse) CD19: Y: relapsed or refractory diffuse large B-cell lymphoma Talacotuzumab ...

7. CD5 (protein) - Wikipedia

   en.wikipedia.org/wiki/CD5_(protein)

   CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell lymphoma (both being B cell malignancies), that do not express CD3.

8. Loncastuximab tesirine - Wikipedia

   en.wikipedia.org/wiki/Loncastuximab_tesirine

   Loncastuximab tesirine, sold under the brand name Zynlonta, is a monoclonal antibody conjugate medication used to treat large B-cell lymphoma and high-grade B-cell lymphoma. [1] [2] It is an antibody-drug conjugate (ADC) composed of a humanized antibody targeting the protein CD19. [1]

9. Diffuse large B-cell lymphoma - Wikipedia

   en.wikipedia.org/wiki/Diffuse_large_B-cell_lymphoma

   Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies.It is the most common form of non-Hodgkin lymphoma among adults, [1] with an annual incidence of 7–8 cases per 100,000 people per year in the US and UK.