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Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, [1] for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or ...
Syngeneic refers to a graft transferred between genetically identical animals or people. [1] A syngeneic graft is known as an isograft. [2] Related terms include: [citation needed] autogeneic, referring to autotransplantation, also termed autograft, (from one part of the body to another in the same person)
According to a 2015 review article, Lewis lung carcinoma is the only reproducable syngeneic lung cancer model, meaning that it is the only reproducible lung cancer model that utilizes a transplant that is immunologically compatible. Syngeneic models have proven to be useful in predicting clinical benefit of therapy in preclinical experiments.
Post-HSCT oral cancer may have more aggressive behavior with poorer prognosis, when compared to oral cancer in non-HSCT patients. [ 63 ] A meta-analysis showed that the risk of secondary cancers such as bone cancer , head and neck cancers , and melanoma , with standardized incidence ratios of 10.04 (3.48–16.61), 6.35 (4.76–7.93), and 3.52 ...
[10] [11] [12] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). [10] [11] It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. [11]
Tumor-associated immune cells in the tumor microenvironment (TME) of breast cancer models. Cancer immunology (immuno-oncology) is an interdisciplinary branch of biology and a sub-discipline of immunology that is concerned with understanding the role of the immune system in the progression and development of cancer; the most well known application is cancer immunotherapy, which utilises the ...
Syngeneic stem cell transplantation is a procedure in which a patient receives blood-forming stem cells (cells from which all blood cells develop) donated by his or her healthy identical twin. References
This process is necessary for immunity against most tumors [2] and against viruses that infect dendritic cells and sabotage their presentation of virus antigens. [3] [4] Cross presentation is also required for the induction of cytotoxic immunity by vaccination with protein antigens, for example, tumour vaccination. [5]