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Autosomal dominant GTP cyclohydrolase I deficiency; Other names: Autosomal dominant Segawa syndrome (the autosomal recessive form of Segawa syndrome is caused by mutations in a different gene that encodes tyrosine hydroxylase), Dopa-responsive dystonia 5a, Autosomal dominant DYT/PARK-GCH1 (designation in accordance with the Nomenclature of Genetic Movement Disorders maintained by the ...
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cephalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or streptococcal tonsillitis, urinary tract infection, reproductive tract infection, and skin infections.
Autosomal recessive GTP cyclohydrolase I deficiency (AR-GTPCHD) is a disorder associated with the deficient operation of the enzyme GTP cyclohydrolase I.The condition leads to insufficient production of the cofactor tetrahydrobiopterin necessary for the proper synthesis of dopamine and serotonin and for maintenance of adequate levels of phenylalanine.
New standard tuning (NST) is an alternative tuning for the guitar that approximates all-fifths tuning.The guitar's strings are assigned the notes C2-G2-D3-A3-E4-G4 (from lowest to highest); the five lowest open strings are each tuned to an interval of a perfect fifth {(C,G),(G,D),(D,A),(A,E)}; the two highest strings are a minor third apart (E,G).
GTP cyclohydrolases are enzymes that catalyze imidazole ring opening of guanosine triphosphate (GTP). [1] This reaction is the committed step in the biosynthesis of multiple coenzymes (such as riboflavin and folate ), tRNA bases , and the phytotoxin toxoflavin . [ 1 ]
Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription process. Its structure is similar to that of the guanosine nucleoside , the only difference being that nucleotides like GTP have phosphates on their ribose sugar.
Cefalexin, also spelled cephalexin, is an antibiotic that can treat a number of bacterial infections. [4] It kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. [ 4 ]
G proteins can bind either GDP or GTP. When bound to GDP, G proteins are inactive. When a ligand binds a GPCR, an allosteric change in the G protein is triggered, causing GDP to leave and be replaced by GTP. [39] GTP activates the alpha subunit of the G protein, causing it to dissociate from the G protein and act as a downstream effector. [39]