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The Toxin and Toxin-Target Database (T3DB), [1] [2] also known as the Toxic Exposome Database, is a freely accessible online database of common substances that are toxic to humans, along with their protein, DNA or organ targets. The database currently houses nearly 3,700 toxic compounds or poisons described by nearly 42,000 synonyms.
The exposome encompasses the set of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome. The exposome was first proposed in 2005 by cancer epidemiologist Christopher Paul Wild in an article entitled "Complementing the genome with an "exposome": the outstanding challenge of environmental exposure ...
For example, the genome contains the ORFeome, which gives rise to the transcriptome, which is translated to the proteome. Other terms are overlapping and refer to the structure and/or function of a subset of proteins (e.g. glycome, kinome). An omicist is a scientist who studies omeomics, cataloging all the “omics” subfields. [1]
Example representation of the environmental factors characterizing the exposome. The exposome is a concept used to describe environmental exposures that an individual encounters throughout life, and how these exposures impact biology and health. It encompasses both external and internal factors, including chemical, physical, biological, and ...
Exposure science is the study of the contact between humans (and other organisms) and harmful agents within their environment – whether it be chemical, physical, biological, behavioural or mental stressors – with the aim of identifying the causes and preventions of the adverse health effects they result in. [1] [2] This can include exposure within the home, workplace, outdoors or any other ...
Human history or world history is the record of humankind from prehistory to the present. Modern humans evolved in Africa around 300,000 years ago and initially lived as hunter-gatherers . They migrated out of Africa during the Last Ice Age and had spread across Earth's continental land except Antarctica by the end of the Ice Age 12,000 years ago.
Biological organization spans several scales and are determined based different structures depending on what the system is. [1] Examples of biological systems at the macro scale are populations of organisms. On the organ and tissue scale in mammals and other animals, examples include the circulatory system, the respiratory system, and the ...
The human and scientific genetic assembly of a natural-based toxin should be considered a toxin as it is identical to its natural counterpart. [15] The debate is one of linguistic semantics . The word toxin does not specify method of delivery (as opposed to venom , a toxin delivered via a bite, sting, etc.).