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Mitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. [4] It is an opioid that is typically consumed as a part of kratom for its pain-relieving and euphoric effects.
Mitragyna speciosa is a tropical evergreen tree of the Rubiaceae family (coffee family) native to Southeast Asia. [3] It is indigenous to Cambodia, Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, [4] where its leaves, known as kratom, have been used in herbal medicine since at least the 19th century. [5]
One Medical was founded by Tom Lee in 2007. The company grew from a single San Francisco clinic to more than 72 locations across the United States, including 29 clinics in the greater San Francisco Bay Area. [3] [4] 1Life Healthcare, Inc. serves as an administrative and managerial services company for physician-owned professional corporations. [7]
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Because the plant has not been well-studied in high-quality clinical research, little is known about its toxicology, adverse effects, or safety over long-term consumption. [ 3 ] [ 4 ] Its chief active psychoactive constituent is a structurally unique diterpenoid called salvinorin A , [ 4 ] [ 12 ] [ 13 ] a potent κ-opioid agonist . [ 14 ]
Amazon Prime electric delivery vans in north London. In 2005, Amazon announced Amazon Prime as a membership service offering free two-day shipping within the contiguous United States on all eligible purchases for an annual fee of $79 (equivalent to $127 in 2024) [4] and discounted one-day shipping rates. [5]
Amazon Pharmacy is an American online pharmacy which is a subsidiary of Amazon. The business was launched on November 17, 2020, initially offering pharmacy service only in the United States . Launch and business model
The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedicated entirely to health science and life science. It conducts research and teaching in medical and biological sciences.