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Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. [3] Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. [4]
True homologs of integrins exist in mammals, invertebrates, and some fungi but not in plant cells. Mammalian integrins are heterodimer transmembrane proteins that play a large role in bidirectional signal transduction. [1] As transmembrane proteins, integrins connect the extracellular matrix (ECM) to the plasma membrane of the animal cell. [1]
All integrins, alpha and beta forms, have large extracellular and short intracellular domains. [7] The cytoplasmic domain of integrin beta-1 binds to the actin cytoskeleton . [ 8 ] Integrin beta-1 is the most abundant beta-integrin expressed and associates with at least 10 different integrin-alpha subunits.
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events. Proteins responsible for detecting stimuli are generally termed receptors , although in some cases the term sensor is used. [ 1 ]
15894 Ensembl ENSG00000090339 ENSMUSG00000037405 UniProt P05362 P13597 RefSeq (mRNA) NM_000201 NM_010493 RefSeq (protein) NP_000192 NP_034623 Location (UCSC) Chr 19: 10.27 – 10.29 Mb Chr 9: 20.93 – 20.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (C luster of D ifferentiation 54) is a protein that in humans is ...
ITGAL gene encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed in all leukocytes.
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are associated with cardiomyopathies. [5] [6] It is a 59kDa protein originally identified in a yeast-two hybrid screen with integrin β1 as the bait protein. [7]
3685 16410 Ensembl ENSG00000138448 ENSMUSG00000027087 UniProt P06756 P43406 RefSeq (mRNA) NM_001144999 NM_001145000 NM_002210 NM_008402 NM_001398691 RefSeq (protein) NP_001138471 NP_001138472 NP_002201 NP_032428 NP_001385620 Location (UCSC) Chr 2: 186.59 – 186.68 Mb Chr 2: 83.55 – 83.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Integrin alpha-V is a protein that in humans ...