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Peak levels of quetiapine occur 1.5 hours after a dose. [87] The plasma protein binding of quetiapine is 83%. [87] The major active metabolite of quetiapine is norquetiapine (N-desalkylquetiapine). [68] Quetiapine has an elimination half-life of 6 or 7 hours. [87] [7] [8] Its metabolite, norquetiapine, has a half-life of 9 to 12 hours.
Etizolam overdose deaths are rising - for instance, the National Records of Scotland report on drug-related deaths, implicated 548 deaths from 'street' Etizolam in 2018, almost double the number from 2017 (299) and only six years from the first recorded death (in 2012). The 548 deaths were 45% of all drug-related deaths in Scotland in 2018. [59]
A postulated "spectrum concept" of serotonin toxicity emphasises the role that progressively increasing serotonin levels play in mediating the clinical picture as side effects merge into toxicity. The dose-response relationship is the effect of progressive elevation of serotonin, either by raising the dose of one drug, or combining it with ...
Benzodiazepine withdrawal syndrome (BZD withdrawal) is the cluster of signs and symptoms that may emerge when a person who has been taking benzodiazepines as prescribed develops a physical dependence on them and then reduces the dose or stops taking them without a safe taper schedule.
Oct. 21—As the number of opioid overdose deaths continues to surge across the United States, some experts stress the urgency of providing the addiction treatment medication buprenorphine to drug ...
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN). When appropriate, protection levels are automatically sensed, described and categorized.
Barbiturate overdose may occur by accident or purposefully in an attempt to cause death. [3] The toxic effects are additive to those of alcohol and benzodiazepines. [3] The lethal dose varies with a person's tolerance and how the drug is taken. [3] The effects of barbiturates occur via the GABA neurotransmitter. [2]
The family of Conrad Dobler, once regarded as the dirtiest player in the NFL, said he had CTE based on a study of his brain after his death in 2023.