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  2. Levofloxacin - Wikipedia

    en.wikipedia.org/wiki/Levofloxacin

    Package inserts mention that levofloxacin is to be avoided in patients with a known hypersensitivity to levofloxacin or other quinolone drugs. [3] [36] Like all fluoroquinolines, levofloxacin is contraindicated in patients with epilepsy or other seizure disorders, and in patients who have a history of quinolone-associated tendon rupture. [3] [36]

  3. Ofloxacin - Wikipedia

    en.wikipedia.org/wiki/Ofloxacin

    Plasma elimination half-life is around 4 to 5 hours in patients and 6.4 to 7.4 hours in elderly patients. [9] Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin. [52]

  4. List of investigational sleep drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_investigational...

    This is a list of investigational sleep drugs, or drugs for the treatment of sleep disorders that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

  5. Why the FDA Rejected This New Insomnia Drug - AOL

    www.aol.com/news/2013-07-01-why-the-fda-rejected...

    Shares of Merck closed flat as the market digests the FDA rejection of new insomnia drug suvorexant. However, this rejection is not out of the blue despite a positive FDA advisory committee vote ...

  6. Lemborexant - Wikipedia

    en.wikipedia.org/wiki/Lemborexant

    Lemborexant is used in the treatment of insomnia in adults. [3]A major systematic review and network meta-analysis of medications for the treatment of insomnia published in 2022 found that lemborexant had an effect size (standardized mean difference (SMD)) against placebo for treatment of insomnia at 4 weeks of 0.36 (95% CI Tooltip confidence interval 0.08 to 0.63) and at 3 months of 0.41 (95% ...

  7. Beers criteria - Wikipedia

    en.wikipedia.org/wiki/Beers_Criteria

    Drugs listed on the Beers List are categorized according to risks for negative outcomes. The tables include medications that have cautions, should be avoided, should be avoided with concomitant medical conditions, and are contraindicated and relatively contraindicated in the elderly population.

  8. Who is eligible for the new FDA-approved Alzheimer's drug? - AOL

    www.aol.com/lifestyle/explainer-eligible-fda...

    The U.S. Food and Drug Administration on Thursday granted standard approval to Eisai and Biogen's Leqembi for patients with Alzheimer's disease. The FDA decision is expected to trigger broader ...

  9. Orexin antagonist - Wikipedia

    en.wikipedia.org/wiki/Orexin_antagonist

    An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonist or DORA) of the orexin receptors, OX 1 and OX 2. [1] Medical applications include treatment of sleep disorders such as ...

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