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Prochymal is a stem cell therapy made by Osiris Therapeutics. It is the first stem cell therapy approved by Canada. It is also the first therapy approved by Canada for acute graft-vs-host disease (GvHD). [1] Also known as remestemcel-L, Prochymal was sold to Australia-based Mesoblast in 2013 [2] at which time its brand name was changed to Ryoncil.
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
Bone marrow transplant is a form of stem cell therapy that has been used for many years because it has proven to be effective in clinical trials. [94] [95] Stem cell implantation may help in strengthening the left-ventricle of the heart, as well as retaining the heart tissue to patients who have suffered from heart attacks in the past. [96]
The Stem Cell Network (SCN) is a Canadian non-profit that supports stem cell and regenerative medicine research, teaches the next generation of highly qualified personal, and delivers outreach activities across Canada. [1] [2] The Network has been supported by the Government of Canada, since inception in 2001.
While there are four drugs used to treat aspects of SCD — three of which were approved between 2017 and 2019 — the only potential cure for the condition has been a stem cell transplant.
A stem cell possesses two properties: . Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. Stem cells can replicate several times and can result in the formation of two stem cells, one stem cell more differentiated than the other, or two differentiated cells.
Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, [1] for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or ...
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).