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  2. Hybridoma technology - Wikipedia

    en.wikipedia.org/wiki/Hybridoma_technology

    A general representation of the hybridoma method used to produce monoclonal antibodies. Hybridoma technology is a method for producing large numbers of identical antibodies, also called monoclonal antibodies. This process starts by injecting a mouse (or other mammal) with an antigen that provokes an immune response.

  3. Bispecific monoclonal antibody - Wikipedia

    en.wikipedia.org/wiki/Bispecific_monoclonal_antibody

    The original concept of BsAbs was proposed by Nisonoff and his collaborators in the 1960s, including the first idea of antibody architecture and other findings. [4] [5] In 1975, the problem of producing pure antibodies was solved by the creation of hybridoma technology, and the new era of monoclonal antibodies (MoAbs) came. [6]

  4. Hypoxanthine-guanine phosphoribosyltransferase - Wikipedia

    en.wikipedia.org/wiki/Hypoxanthine-guanine...

    n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is an enzyme encoded in humans by the HPRT1 gene. HGPRT is a transferase that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. This ...

  5. Monoclonal antibody therapy - Wikipedia

    en.wikipedia.org/wiki/Monoclonal_antibody_therapy

    Anti-cancer monoclonal antibodies can be targeted against malignant cells by several mechanisms. Ramucirumab is a recombinant human monoclonal antibody and is used in the treatment of advanced malignancies. [18] In childhood lymphoma, phase I and II studies have found a positive effect of using antibody therapy. [19]

  6. Applied Biosystems - Wikipedia

    en.wikipedia.org/wiki/Applied_Biosystems

    The public consortium also bought one of the PE Biosystems 3700 sequencers, and had plans to buy 200 more. The machine proved to be so fast that by late March 1999 the consortium announced that it had revised its timeline, and would release by the Spring of 2000 a "first draft sequence" for 80% of the human genome. [18]

  7. Celera Corporation - Wikipedia

    en.wikipedia.org/wiki/Celera_Corporation

    Celera Corporation is a subsidiary of Quest Diagnostics which focuses on genetic sequencing and related technologies. It was founded in 1998 as a business unit of Applera , spun off into an independent company in 2008, and finally acquired by Quest Diagnostics in 2011.

  8. Humanized antibody - Wikipedia

    en.wikipedia.org/wiki/Humanized_antibody

    Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants produced naturally in humans. [ 1 ] [ 2 ] The process of "humanization" is usually applied to monoclonal antibodies developed for administration to humans (for example, antibodies developed as ...

  9. Developmental Studies Hybridoma Bank - Wikipedia

    en.wikipedia.org/wiki/Developmental_studies...

    The DSHB is directed by David R. Soll at the University of Iowa. There are currently over 5000 hybridomas in the DSHB collection. [1] The DSHB has obtained hybridomas from a variety of individuals and institutions, the latter including the Muscular Dystrophy Association, the National Cancer Institute, the NIH Common Fund, and the European Molecular Biology Laboratory (EMBL).

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