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Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.
Bacteria: Escherichia coli (E. coli), common Gram-negative gut bacterium widely used in molecular genetics. Main lab strain is 'K-12'. Bacillus subtilis, endospore forming Gram-positive bacterium. Main lab strain is '168'. Caulobacter crescentus, bacterium that divides into two distinct cells used to study cellular differentiation.
Bacteriophages introduce a gene into the bacterial cells that makes a strain toxigenic. The strains that are not infected with these viruses are harmless. [5] C. diphtheriae is a rod-shaped, Gram-positive, non spore-forming, and nonmotile bacterium. [17] C. diphtheriae has shown to exclusively infect humans. It is believed that humans may be ...
An example of a virus that uses the lysogenic cycle to its advantage is the Herpes Simplex Virus. [10] After first entering the lytic cycle and infecting a human host, it enters the lysogenic cycle. This allows it to travel to the nervous system's sensory neurons and remain undetected for long periods of time.
Clostridium is a genus of anaerobic, Gram-positive bacteria.Species of Clostridium inhabit soils and the intestinal tracts of animals, including humans. [1] This genus includes several significant human pathogens, including the causative agents of botulism and tetanus.
The human phageome is thought to be brought about in newborns through prophage induction of bacteria passed on from the mother vaginally during birth. [12] However, phages can be introduced through breastfeeding, made evident through studies finding near-exact matches of crAssphage sequences between mother and child. [ 12 ]
For example, the antibiotics chloramphenicol and tetracyclin inhibit the bacterial ribosome but not the structurally different eukaryotic ribosome, so they exhibit selective toxicity. [28] Antibiotics are used both in treating human disease and in intensive farming to promote animal growth.
During fd phage assembly, the phage DNA is first packaged into a linear intracellular nucleoprotein complex with many copies of the phage gene 5 replication/assembly protein. The gene 5 protein is then displaced by the gene 8 coat protein as the nascent phage is extruded across the bacterial plasma membrane without killing the bacterial host.