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Buruli ulcer is caused by infection of the skin with the bacterium Mycobacterium ulcerans. [1] M. ulcerans is a mycobacterium, closely related to Mycobacterium marinum which infects aquatic animals and, rarely, humans. [9]
Mycobacterium ulcerans is a species of bacteria found in various aquatic environments. The bacteria can infect humans and some other animals, causing persistent open wounds called Buruli ulcer . M. ulcerans is closely related to Mycobacterium marinum , from which it evolved around one million years ago, and more distantly to the mycobacteria ...
The Global Buruli Ulcer Initiative (GBUI) is a World Health Organization (WHO) initiative to coordinate global efforts to control Buruli ulcer, [1] an infectious disease characterized by the development of painless open wounds. [2]
Mycobacteria are a family of small, rod-shaped bacilli that can be classified into three main groups for diagnosis and treatment: Mycobacterium tuberculosis complex, which can cause tuberculosis: M. tuberculosis, M. bovis, M. africanum, M. microti and M. canettii; M. leprae and M. lepromatosis, which cause Hansen's disease, also called leprosy
With multidrug therapy used as the standard treatment of Hansen's disease, rifampicin is always used in combination with dapsone and clofazimine to avoid causing drug resistance. [ citation needed ] It is also used in the treatment of Mycobacterium ulcerans infections as associated with Buruli ulcer , usually in combination with clarithromycin ...
Mycobacterium is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae. This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis (M. tuberculosis) and leprosy in humans.
There is now considerable evidence to suggest that this disease is an infection. Mycobacterium ulcerans has recently been isolated from lesions and is unique to tropical ulcers. [5] Early lesions may be colonized or infected by, Bacillus fusiformis (Vincent's organism), anaerobes and spirochaetes.
Mycolactone is a polyketide-derived macrolide produced and secreted by a group of very closely related pathogenic mycobacteria species including M. ulcerans, M. liflandii (an unofficial designation), M. pseudoshottsii, and some strains of M. marinum. These mycobacteria are collectively referred to as mycolactone-producing mycobacteria or MPM ...