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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells , but also acts on haemopoietic progenitor cells and T cells .
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. [ 7 ] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
The hepatocyte plates are one cell thick in mammals and two cells thick in the chicken. Sinusoids display a discontinuous, fenestrated endothelial cell lining. The endothelial cells have no basement membrane and are separated from the hepatocytes by the space of Disse, which drains lymph into the portal tract lymphatics. [citation needed]
The center grew out of the Pacific Northwest Research Foundation, founded in 1956 by William B. Hutchinson (1909–1997). The Foundation was dedicated to the study of heart surgery, cancer, and diseases of the endocrine system. Hutchinson's younger brother Fred (1919–1964) was a major league pitcher and manager who died of lung cancer at age ...
Conditional knockout studies show that Foxa2 is important for the formation of pancreatic islets and maturation of alpha and beta cells, thereby being essential for glucose homeostasis. [ 25 ] [ 26 ] Dysregulation of FOXA transcription factors have been linked to several types of human cancers, including acute myeloid leukemia and cancer of the ...
Micro-mass cultures of C3H-10T1/2 cells at varied oxygen tensions stained with Alcian blue. A commonly applied definition of tissue engineering, as stated by Langer [3] and Vacanti, [4] is "an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve [Biological tissue] function or a ...
The study had several limitations that future research may address, including a lack of racial and ethnic diversity, which plays an important role in a person’s risk for heart disease. Nearly ...
Sarah Cannon Research Institute (SCRI) is a research organization focusing on therapies for patients which include drugs that are in development. With corporate headquarters in Nashville, Tennessee , United States, it conducts community-based clinical trials in oncology , cardiology , gastroenterology , and other therapeutic areas. [ 1 ]