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  2. Cerebral atrophy - Wikipedia

    en.wikipedia.org/wiki/Cerebral_atrophy

    Cerebral atrophy is a common feature of many of the diseases that affect the brain. [1] Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins.

  3. Batten disease - Wikipedia

    en.wikipedia.org/wiki/Batten_disease

    Over time, affected children experience mental impairment, worsening seizures and progressive loss of sight, speech and motor skills. Batten disease is a terminal disease; life expectancy varies depending on the type or variation. [7] [8] Females with juvenile Batten disease show first symptoms a year later than males, but on average die a year ...

  4. Gerstmann–Sträussler–Scheinker syndrome - Wikipedia

    en.wikipedia.org/wiki/Gerstmann–Sträussler...

    Universally fatal, life expectancy is typically 5-6 years from diagnosis Gerstmann–Sträussler–Scheinker syndrome ( GSS ) is an extremely rare, always fatal (due to it being caused by prions ) neurodegenerative disease that affects patients from 20 to 60 years in age.

  5. Progressive supranuclear palsy - Wikipedia

    en.wikipedia.org/wiki/Progressive_supranuclear_palsy

    Progressive supranuclear palsy (PSP) is a late-onset neurodegenerative disease involving the gradual deterioration and death of specific volumes of the brain. [1] [2] The condition leads to symptoms including loss of balance, slowing of movement, difficulty moving the eyes, and cognitive impairment. [1]

  6. Bing–Neel syndrome - Wikipedia

    en.wikipedia.org/wiki/Bing–Neel_syndrome

    Bing–Neel syndrome (BNS) is an extremely rare neurologic complication of Waldenström macroglobulinemia (WM), which is a chronic lymphoproliferative disorder. [1] There's no clear definition of BNS but what is known so far is that unlike WM, It involves the central nervous system (CNS), infiltrated by differentiated malignant B cells and by having hyperglobulinemia. [2]

  7. Spongy degeneration of the central nervous system - Wikipedia

    en.wikipedia.org/wiki/Spongy_degeneration_of_the...

    Affected children typically die before the age of 10, but life expectancy can vary. [5] The cause of spongy degeneration of the CNS is the mutation in a gene coding for aspartoacylase (AspA), an enzyme that hydrolyzes N-acetyl aspartic acid (NAA). [6] In the absence of AspA, NAA accumulates and results in spongy degeneration. [7]

  8. Multiple system atrophy - Wikipedia

    en.wikipedia.org/wiki/Multiple_system_atrophy

    [80] Kenneth More British actor, originally diagnosed with Parkinson's disease. Chef Kerry Simon died from complications of MSA. [81] David Colin Sherrington FRS (1945–2014), noted polymer chemist, who was diagnosed in 2012 and died from pneumonia two years later. Karsten Heuer (1968-2024) Canadian Biologist, Conservationist, Filmmaker and ...

  9. Lissencephaly - Wikipedia

    en.wikipedia.org/wiki/Lissencephaly

    Lissencephaly (/ ˌ l ɪ s. ɛ n ˈ s ɛ f. ə l. i /, meaning 'smooth brain') [1] is a set of rare brain disorders whereby the whole or parts of the surface of the brain appear smooth. [2] It is caused by defective neuronal migration during the 12th to 24th weeks of gestation, resulting in a lack of development of brain folds and grooves . [3]