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Myostatin inhibitors were generally able to increase lean body mass and reduce body fat in people with sarcopenia, but the extent to which this translated into functional improvements varied. [ 11 ] Bimagrumab showed effectiveness in increasing lean mass and reducing fat mass in obese individuals in a clinical trial.
Two common but distinct conditions characterized by a loss of skeletal muscle mass are sarcopenia and cachexia. [52] Sarcopenia and cachexia represent the major causes of muscle-wasting disorders. It has been known for millennia that muscle and fat wasting leads to poor outcomes, including deaths in chronic disease states.
Sarcopenic obesity is a combination of two disease states, sarcopenia and obesity. Sarcopenia is the muscle mass/strength/physical function loss associated with increased age, [ 1 ] and obesity is based off a weight to height ratio or body mass index (BMI) that is characterized by high body fat or being overweight.
Sarcopenia is considered a component of frailty syndrome. [2] Sarcopenia can lead to reduced quality of life, falls, fracture, and disability. [3] [4] Sarcopenia is a factor in changing body composition. When associated with aging populations, certain muscle regions are expected to be affected first, specifically the anterior thigh and ...
Cachexia (/ k ə ˈ k ɛ k s i ə / [1]) is a syndrome that happens when people have certain illnesses, causing muscle loss that cannot be fully reversed with improved nutrition. [2] It is most common in diseases like cancer, congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease, and AIDS.
They have been investigated in human studies for the treatment of osteoporosis, cachexia, benign prostatic hyperplasia, stress urinary incontinence, prostate cancer, and breast cancer and have also been considered for the treatment of Alzheimer's disease, Duchenne muscular dystrophy, hypogonadism and as a male contraceptive.
Sarcopenia is defined as loss of muscle tissue as a natural part of the aging process. [3] This does not include loss of muscle strength, which is defined by dynapenia. Muscle strength appears to be a critical component in maintaining physical function, mobility, and vitality in old age, which is why it's imperative to identify and study contributing factors of dyna
ACE-083, a follistatin-based fusion protein, was investigated for treatment focal or asymmetric myopathies. Intramuscular ACE-083 increased growth and force production in injected muscle in wild-type mice and mouse models of Charcot-Marie-Tooth disease (CMT) and Duchenne muscular dystrophy , without systemic effects or endocrine disruption.
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