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The ideal vaginal microbicide would have the following characteristics: provide protection against infection not require application at the time of intercourse not harm the natural tissue [3] As of 2009, not harming natural tissue was the most troublesome aspect of development.
Results released in February 2009 from a clinical trial of PRO 2000 (Indevus Pharmaceuticals), a vaginal-microbicide gel (0.5%), sparked hope that it might provide modest protection against HIV. [22] The results of a larger trial released in December 2009 showed that PRO 2000 was safe as administered, but was ineffective in reducing the risk of ...
Administering a vaginal tablet without an applicator. Intravaginal administration is a route of administration where the substance is applied inside the vagina . Pharmacologically , it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix ) with limited systemic ...
For example, a vaginal gel formulation of tenofovir and an intravaginal ring releasing dapivirine are under investigation for efficacy. [17] Out of three completed trials evaluating safety and efficacy of tenofovir vaginal gel, only the CAPRISA 004 trial showed the drug to be efficacious in decreasing the risk of HIV infection.
Pre-filled syringes of vaginal tightening gel. Over 2,500 syringes filled with dangerous “vaginal tightening gel,” coming from Hong Kong, were seized at the Minneapolis-St. Paul Airport.
The contraceptive vaginal ring has a failure rate of 0.3% when used as prescribed and 9% when used typically. [7] [9] The correlation between breast cancer and the use of vaginal rings is under investigation, but recent literature suggests that the hormones used in vaginal rings has little, if any, relation to the risk of developing breast ...
Fenticonazole or its metabolites cross the placental barrier in pregnant rats and rabbits after vaginal application and are excreted in milk of lactating rats. Since there is no experience of use during pregnancy or lactation, fenticonazole nitrate vaginal capsules should not be used unless the physician considers if essential to the welfare of ...
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. [2] [7] It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For ...
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