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This is a list of progestogens (progesterone and progestins) and formulations that are approved by the FDA Tooltip Food and Drug Administration in the United States. Progestogens are used as hormonal contraceptives, in hormone replacement therapy for menopausal symptoms, and in the treatment of gynecological disorders.
Available forms of progesterone [sources 1] [a] Route Form Dose Brand name Availability [b] Oral: Capsule: 100, 200, 300 mg: Prometrium [c] Widespread Tablet (SR)
Ulipristal acetate, sold under the brand name Ella among others, is a medication used for emergency contraception (birth control) and uterine fibroids. [1] [7] [8] As emergency contraception it should be used within 120 hours of vaginally penetrating intercourse. [1]
Progesterone. Steroid ring system. This is a list of progestogens that are or that have been used in clinical or veterinary medicine. They are steroids and include derivatives of progesterone and testosterone.
Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.
Quingestrone (Enol-Luteovis) is a progesterone ether (specifically, the 3-cyclopentyl ether of progesterone) that has been marketed in Italy as an oral contraceptive. [ 18 ] [ 19 ] Quingestrone is a variant of progesterone with improved pharmacokinetics, including higher potency, oral activity, greater lipophilicity, and a longer half-life.
Progesterone interacts with membrane progesterone receptors, but interaction of progestins with these receptors is less clear. [ 165 ] [ 166 ] In addition to their progestogenic activity, many progestogens have off-target activities such as androgenic , antiandrogenic , estrogenic , glucocorticoid , and antimineralocorticoid activity.
Progesterone is the major progestogen produced by the corpus luteum of the ovary in all mammalian species. Luteal cells possess the necessary enzymes to convert cholesterol to pregnenolone, which is subsequently converted into progesterone. Progesterone is highest in the diestrus phase of the estrous cycle.