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Some of these uses include acne, seborrhea, hirsutism, and pattern hair loss in women. [39] Spironolactone is used for the treatment of hirsutism in the United States. [40] High doses of spironolactone, which are needed for considerable antiandrogenic effects, are not recommended for men due to the high risk of feminization and other side effects.
The AR antagonism of spironolactone mostly underlies its antiandrogenic activity and is the major mechanism responsible for its therapeutic benefits in the treatment of androgen-dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women.
Specifically, studies suggest that muscle loss with GLP-1s can range from 25 to 39 percent of the total weight loss while muscle loss via caloric restriction (with less total weight loss) ranges ...
Beyond weight loss, berberine also has a few other possible, intriguing benefits. Recent research has investigated berberine’s role in supporting heart health and lowering blood sugar levels ...
SGLT2 inhibitors cause the loss of 60–100 grams (2.1–3.5 oz) glucose in the urine each day and are associated with a modest, sustained weight loss of 1.5–2 kilograms (3.3–4.4 lb) in people with type 2 diabetes. The weight loss is less than expected due to compensatory increases in energy intake, but is additive when combined with GLP-1 ...
GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. ... that. In one study of people on liraglutide (Saxenda ...
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