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Valproate may cause increased somnolence in the elderly. In a trial of valproate in elderly patients with dementia, a significantly higher portion of valproate patients had somnolence compared to placebo. In approximately one-half of such patients, there was associated reduced nutritional intake and weight loss.
Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication. Depakene is the trade name for the same drug prepared without sodium. Desyrel – an atypical antidepressant used to treat depression and insomnia
[27] [4] It affects about 6% of people 65 years and older, [16] and women more often than men. [28] The disease is named after German psychiatrist and pathologist Alois Alzheimer, who first described it in 1906. [29] Alzheimer's financial burden on society is large, with an estimated global annual cost of US$1 trillion. [14]
Between May 2007 and April 2008, Dementia and Alzheimer's together accounted for 28% of atypical antipsychotic use in patients aged 65 or older. [46] The U.S. Food and Drug Administration requires that all atypical antipsychotics carry a black box warning that the medication has been associated with an increased risk of mortality in elderly ...
From the age of 60 years (10%) to the age of 80 years (60%), the proportion of people with senile plaques increases linearly. Women are slightly more likely to have plaques than are men. [45] [44] Both plaques and Alzheimer's disease also are more common in aging persons with trisomy-21 (Down syndrome).
Multi-infarct dementia results from a series of small strokes affecting several brain regions. Stroke-related dementia involving successive small strokes causes a more gradual decline in cognition. [4] Dementia may occur when neurodegenerative and cerebrovascular pathologies are mixed, as in susceptible elderly people (75 years and older).
The prevention of dementia involves reducing the number of risk factors for the development of dementia, and is a global health priority needing a global response. [1] [2] Initiatives include the establishment of the International Research Network on Dementia Prevention (IRNDP) [3] which aims to link researchers in this field globally, and the establishment of the Global Dementia Observatory ...
Between 5% and 25% of diagnosed dementias in older adults are due to one of the Lewy body dementias. [14] [a] As of 2014, the Lewy body dementias affect about 1.3 million people in the US and 140,000 in the UK. [6] LBD usually develops after the age of 50. [8] Men are more likely to be diagnosed than women. [8]
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