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In 1905, Fritz Schaudinn and Erich Hoffmann discovered Treponema pallidum in tissue of patients with syphilis. [2] One year later, the first effective test for syphilis, the Wassermann test, was developed. Although it had some false positive results, it was a major advance in the detection and prevention of syphilis.
The Wassermann test or Wassermann reaction (WR) [1] is an antibody test for syphilis, named after the bacteriologist August Paul von Wassermann, based on complement fixation. It was the first blood test for syphilis and the first in the nontreponemal test (NTT) category. Newer NTTs, such as the RPR and VDRL tests, have mostly
The Venereal Disease Research Laboratory test (VDRL) is a blood test for syphilis and related non-venereal treponematoses that was developed by the eponymous US laboratory. The VDRL test is used to screen for syphilis (it has high sensitivity ), whereas other, more specific tests are used to diagnose the disease.
Syphilis tests are generally available at low cost with insurance, she added. ... While case rates were rising in Spokane, there were 9.2 syphilis cases per 100,000 residents statewide in 2017 ...
Syphilis is typically spread through direct contact with a syphilis sore, known as a chancre, during vaginal, anal or oral sex. It can also be passed from a pregnant person to a child during birth.
Nontreponemal tests are screening tests, very rapid and relatively simple, but need to be confirmed by treponemal tests. [1] Centers for Disease Control and Prevention (CDC)-approved standard tests include the VDRL test (a slide test), the rapid plasma reagin (RPR) test (a card test), the unheated serum reagin (USR) test, and the toluidine red ...
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