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  2. Acetylcholinesterase - Wikipedia

    en.wikipedia.org/wiki/Acetylcholinesterase

    Acetylcholinesterase (HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters :

  3. Cholinesterase - Wikipedia

    en.wikipedia.org/wiki/Cholinesterase

    Acetylcholinesterase (EC 3.1.1.7) (ACHE), also known as AChE, choline esterase I, RBC cholinesterase, or erythrocyte cholinesterase, true cholinesterase, choline esterase I, or (most formally) acetylcholine acetylhydrolase, is found primarily in the blood on red blood cell membranes, in neuromuscular junctions, and in other neural synapses ...

  4. Acetylcholinesterase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor

    Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, [1] inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, [2] thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and ...

  5. Neuromuscular junction - Wikipedia

    en.wikipedia.org/wiki/Neuromuscular_junction

    Active zones are about 1 micrometer apart. The 30 nanometer cleft between nerve ending and endplate contains a meshwork of acetylcholinesterase (AChE) at a density of 2,600 enzyme molecules/μm 2, held in place by the structural proteins dystrophin and rapsyn.

  6. PRIMA1 - Wikipedia

    en.wikipedia.org/wiki/PRIMA1

    145270 170952 Ensembl n/a ENSMUSG00000041669 UniProt Q86XR5 Q810F0 RefSeq (mRNA) NM_178004 NM_178013 NM_133364 NM_178023 RefSeq (protein) NP_821092 NP_821092.1 NP_579942 Location (UCSC) n/a Chr 12: 103.16 – 103.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Proline-rich membrane anchor 1, also known as PRiMA, is a protein that in humans is encoded by the PRIMA1 gene. Function ...

  7. Cholinesterase reactivator - Wikipedia

    en.wikipedia.org/wiki/Cholinesterase_reactivator

    Acetylcholinesterase Inhibitors Organophosphates lead to toxicity by forming a strong covalent bond in the active site of AChE. OPs phosphorylate the serine residue in the active site of AChE, irreversibly inhibiting the enzyme, thereby allowing acetylcholinesterase to accumulate in the synaptic cleft of ACh receptors.

  8. Acetylcholine - Wikipedia

    en.wikipedia.org/wiki/Acetylcholine

    Acetylcholine is a choline molecule that has been acetylated at the oxygen atom. Because of the charged ammonium group, acetylcholine does not penetrate lipid membranes. . Because of this, when the molecule is introduced externally, it remains in the extracellular space and at present it is considered that the molecule does not pass through the blood–brain

  9. Neuromuscular-blocking drug - Wikipedia

    en.wikipedia.org/wiki/Neuromuscular-blocking_drug

    Also, tubocurarine effects were known to be reversible by acetylcholinesterase inhibitors, whereas decamethonium and suxamethonium block were not reversible. [9] [5] Another compound malouétine that was a bis-quaternary steroid was isolated from the plant Malouetia bequaertiana and showed curariform activity.