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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [ 1 ] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
ScaRNAs guide the modification (methylation and pseudouridylation) of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. The first scaRNA identified was U85. [1] It is unlike typical snoRNAs in that it is a composite C/D box and H/ACA box snoRNAs and can guide both pseudouridylation and 2′-O-methylation.
S-adenosyl-L-methionine + guanosine 2922 in 27S pre-rRNA S-adenosyl-L-homocysteine + 2'-O-methylguanosine 2922 in 27S pre-rRNA Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922.
In multicellular eukaryotes and some viruses, [8] further modifications can be made, including the methylation of the 2′ hydroxy-groups of the first 2 ribose sugars of the 5′ end of the mRNA. cap-1 has a methylated 2′-hydroxy group on the first ribose sugar, while cap-2 has methylated 2′-hydroxy groups on the first two ribose sugars ...
Ribosomes are the macromolecular machines that are responsible for mRNA translation into proteins. The eukaryotic ribosome, also called the 80S ribosome, is made up of two subunits – the large 60S subunit (which contains the 25S [in plants] or 28S [in mammals], 5.8S, and 5S rRNA and 46 ribosomal proteins) and a small 40S subunit (which contains the 18S rRNA and 33 ribosomal proteins). [6]
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Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs. [1] HBII-55 is predicted to guide the 2′O-ribose methylation of 18S ribosomal RNA (rRNA) at residue U1288.