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Topical antifungal drugs are used to treat fungal infections on the skin, scalp, nails, vagina or inside the mouth. These medications come as creams, gels, lotions, ointments, powders, shampoos, tinctures and sprays. Most antifungal drugs induce fungal cell death by destroying the cell wall of the fungus.
Sudocrem (/ ˈ s u d ə k r ɛ m / or / ˈ s u d ə k r i m / in Ireland) [3] is an over-the-counter medicated cream aimed primarily at the treatment of irritant diaper dermatitis.It contains a water-repellent base (consisting of oils/waxes); protective and moisturizer agents; antibiotic and antifungal agents; and a weak anesthetic.
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. [11] Applied to the skin it is used for fungal skin infections such as tinea, cutaneous candidiasis, pityriasis versicolor, dandruff, and seborrheic dermatitis. [12]
Additionally, it has been used for acne, dermatitis herpetiformis, and various other skin conditions. [5] Dapsone is available both topically and by mouth. [6] Severe side effects may include a decrease in blood cells, red blood cell breakdown especially in those with glucose-6-phosphate dehydrogenase deficiency (G-6-PD), or hypersensitivity. [4]
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema. [2] Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff. [2]
Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others. [6] It is also used to prevent worsening of asthma and chronic obstructive pulmonary disease (COPD). [6] It can be taken in various ways including by mouth, injection into a muscle, and inhalation. [6]
Common side effects include vomiting, diarrhea, rash, and increased liver enzymes. [5] Serious side effects may include liver problems, QT prolongation, and seizures. [5] During pregnancy it may increase the risk of miscarriage while large doses may cause birth defects. [6] [5] Fluconazole is in the azole antifungal family of medication. [5]
Tolnaftate [1] sold under the brand name TAGRID among, others is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol . [ 2 ]
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