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Lysyl oxidase is an extracellular copper-dependent enzyme that catalyzes formation of aldehydes from lysine residues in collagen and elastin precursors. [ 15 ] [ 16 ] These aldehydes react with unmodified lysine residues, resulting in cross-linking collagen and elastin, which is essential for stabilization of collagen fibrils and for the ...
94352 Ensembl ENSG00000134013 ENSMUSG00000034205 UniProt Q9Y4K0 P58022 RefSeq (mRNA) NM_002318 NM_033325 RefSeq (protein) NP_002309 NP_201582 Location (UCSC) Chr 8: 23.3 – 23.43 Mb Chr 14: 69.85 – 69.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Lysyl oxidase homolog 2 is an enzyme that in humans is encoded by the LOXL2 gene. Function This gene encodes a member of the lysyl ...
Formation of the collagen fibril: lysyl oxidase, an extracellular copper-dependent enzyme, produces the final step in the collagen synthesis pathway. This enzyme acts on lysines and hydroxylysines producing aldehyde groups, which will eventually undergo covalent bonding between tropocollagen molecules.
Lysyl hydroxylases (or procollagen-lysine 5-dioxygenases) are alpha-ketoglutarate-dependent hydroxylases enzymes that catalyze the hydroxylation of lysine to hydroxylysine. [1][2] Lysyl hydroxylases require iron and vitamin C as cofactors for their oxidation activity. It takes place (as a post-translational modification) following collagen ...
Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene. [5] [6]This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin.
Lysyl oxidase is an important enzyme for the creation of crosslinks between collagen triple-helices in connective tissue. By oxidizing the terminal amino group of lysine, an aldehyde is created. This aldehyde can undergo several reactions with neighboring aldehydes or amines to create strong covalent cross-links between collagen tertiary ...
Elastin. Elastin is a protein encoded by the ELN gene in humans and several other animals. Elastin is a key component in the extracellular matrix of gnathostomes (jawed vertebrates). [5] It is highly elastic and present in connective tissue of the body to resume its shape after stretching or contracting. [6]
Lysyl oxidase homolog 3 is an enzyme that in humans is encoded by the LOXL3 gene.. This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin.
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