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Nuclear DNA (nDNA), or nuclear deoxyribonucleic acid, is the DNA contained within each cell nucleus of a eukaryotic organism. [1] It encodes for the majority of the genome in eukaryotes, with mitochondrial DNA and plastid DNA coding for the rest.
Nuclear DNA refers to the genetic material found within the nucleus of a cell, consisting of two long strands that form a double helix structure. It is composed of nucleotides, which are arranged in a linear order and contain four bases: guanine (G), cytosine (C), adenine (A), and thymine (T).
Usually the genetics of human longevity is restricted to the nuclear genome (nDNA). However it is well known that the nDNA interacts with a physically and functionally separated genome, the mitochondrial DNA (mtDNA) that, even if limited in length ...
The mt-nuclear DNA fusion junctions were distributed throughout the mitochondrial genome (Supplementary Fig. 2f), and the D-loop region exhibited a higher junction density than other mtDNA regions ...
Nuclear DNA encodes the majority of genes that are required for life. The nuclear DNA consists of protein-coding sequences, which account for 2% of the total DNA, and noncoding sequences that include RNA-coding sequences, structural components, regulatory sequences, but also extensive repetitive DNA sequences.
The C-value of the nuclear genome. The complete set of DNA within the nucleus of any organism is called its nuclear genome and is measured as the C-value in units of either the number of base pairs or picograms of DNA. There is a general correlation between the nuclear DNA content of a genome (i.e. the C-value) and the physical size or complexity of an organism.
Despite having its own circular genome, the majority of mitochondrial proteins are encoded by nuclear DNA. To respond to changes in cell physiology, the mitochondria must send signals to the nucleus, which can, in turn, upregulate gene expression to alter metabolism or initiate a stress response. This is known as retrograde signaling.
DNA is non-randomly arranged in the nucleus, with silent chromatin domains preferentially associating with inner nuclear membrane proteins and lamins in yeast and larger eukaryotes,...
José Antonio Enríquez and colleagues look into the effects of mitochondrial DNA sequence variation by using congenic mice strains that share the same nuclear genome, but have different ...
The complete set of DNA within the nucleus of any organism is called its nuclear genome and is measured as the C-value in units of either the number of base pairs or picograms of DNA.