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Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. [5] Signs and symptoms classically include abdominal pain and vaginal bleeding, but fewer than 50 percent of affected women have both of these symptoms. [1] The pain may be described as sharp, dull, or crampy. [1]
Methotrexate. 60% at lower doses, less at higher doses. [7] Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. [4] It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. [4] Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational ...
A rarely used drug combination for uterine pregnancies is methotrexate-misoprostol, which is typically reserved for ectopic pregnancies. [41] Methotrexate is given either orally or intramuscularly, followed by vaginal misoprostol 3–5 days later. [22] The methotrexate combination is available through 63 days.
Ovarian pregnancy refers to an ectopic pregnancy that is located in the ovary. Typically the egg cell is not released or picked up at ovulation, but fertilized within the ovary where the pregnancy implants. [1][2][3] Such a pregnancy usually does not proceed past the first four weeks of pregnancy. [3] An untreated ovarian pregnancy causes ...
Ectopic pregnancy is treated with methotrexate therapy or surgery. Typically, an intramuscular injection of 50 mg per m^2 of methotrexate is given followed by close monitoring of b-hCG levels 4 and 7 days after injection. B-hCG levels should decrease by at least 15% between those two timepoints. [26]
The most commonly addressed by Catholic bioethicists is extrauterine tubal pregnancies in which salpingectomy is seen with consensus to be indirect while some claim salpingostomy and methotrexate to be indirect. [9] [10] [11] Of the other 7-10% of ectopic pregnancies, there are interstitial pregnancy and cesarean scar pregnancy.
As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. Both high-folate diets and supplemental ...
If a viable intrauterine pregnancy is not found with ultrasound, blood tests (serial βHCG tests) can be performed to rule out ectopic pregnancy, which is a life-threatening situation. [107] [108] If hypotension, tachycardia, and anaemia are discovered, the exclusion of an ectopic pregnancy is important. [108]
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