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[h] The authors conclude that if replication is defined by a subsequent study finding a sufficiently similar effect size to the original, replication success is not likely even if replications have very large sample sizes. Importantly, this occurs even if replications are direct or exact since heterogeneity nonetheless remains relatively high ...
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
After one replication, the DNA was found to have intermediate density. Since conservative replication would result in equal amounts of DNA of the higher and lower densities (but no DNA of an intermediate density), conservative replication was excluded. However, this result was consistent with both semiconservative and dispersive replication.
Eukaryotes initiate DNA replication at multiple points in the chromosome, so replication forks meet and terminate at many points in the chromosome. Because eukaryotes have linear chromosomes, DNA replication is unable to reach the very end of the chromosomes. Due to this problem, DNA is lost in each replication cycle from the end of the chromosome.
In engineering, science, and statistics, replication is the process of repeating a study or experiment under the same or similar conditions. It is a crucial step to test the original claim and confirm or reject the accuracy of results as well as for identifying and correcting the flaws in the original experiment. [ 1 ]
The chromosomes of archaea and eukaryotes can have multiple origins of replication, and so their chromosomes may consist of several replicons [citation needed]. The concept of the replicon was formulated in 1963 by François Jacob, Sydney Brenner, and Jacques Cuzin as a part of their replicon model for replication initiation. According to the ...
The replication fork consists of a group of proteins that influence the activity of DNA replication. In order for the replication fork to stall, the cell must possess a certain number of stalled forks and arrest length. The replication fork is specifically paused due to the stalling of helicase and polymerase activity, which are linked together ...
Replication crisis; Self-replication, the process in which an entity (a cell, virus, program, etc.) makes a copy of itself DNA replication or DNA synthesis, the process of copying a double-stranded DNA molecule Semiconservative replication, mechanism of DNA replication; Viral replication, the process by which viruses produce copies of themselves