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The brain volume decreases roughly 5% per decade after forty. It is currently unclear why brain volume decreases with age. However, a few causes may include cell death, decreased cell volume, and changes in synaptic structure.
More recent MRI studies have reported age-related regional decreases in cerebral volume. [6] [7] Regional volume reduction is not uniform; some brain regions shrink at a rate of up to 1% per year, whereas others remain relatively stable until the end of the life-span. [8]
The amygdala, cerebellum, and many other brain regions have been implicated in autism. [15]Unlike some brain disorders which have clear molecular hallmarks that can be observed in every affected individual, such as Alzheimer's disease or Parkinson's disease, autism does not have a unifying mechanism at the molecular, cellular, or systems level.
The volume of the human brain has increased as humans have evolved (see Homininae), starting from about 600 cm 3 in Homo habilis up to 1680 cm 3 in Homo neanderthalensis, which was the hominid with the biggest brain size. [7] Some data suggest that the average brain size has decreased since then. [8]
Mostly in the frontal cortex, these differences often stem from a smaller brain volume, and the decreased blood flow that results influences the hypofrontality. [9] It has not been determined if the reduction of the frontal cortex is the ultimate cause of the symptoms, or if the condition worsens as the symptoms develop.
The earliest attempts at estimating brain volume were done using measures of external head parameters, such as head circumference as a proxy for brain size. [1] More recent methodologies employed to study this relationship include post-mortem measures of brain weight and volume. These have their own limitations and strengths. [9]
Autism in Adulthood is a quarterly peer-reviewed academic journal covering research across a range of disciplines on all aspects of autism spectrum disorders in adults. It was established in 2019 and is published by Mary Ann Liebert. The founding editor-in-chief is Christina Nicolaidis (Portland State University). [1]
The relationship between autism and memory, specifically memory functions in relation to autism spectrum disorder (ASD), is an ongoing topic of research. ASD is a neurodevelopmental disorder characterised by social communication and interaction impairments, along with restricted and repetitive patterns of behavior.