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Hypertensive disorders during pregnancy, such as gestational hypertension, preeclampsia, and eclampsia, are a major contributor to maternal and fetal illness and death on a worldwide scale. Around 5-10% of pregnancies are affected by these conditions, with preeclampsia being responsible for up to 14% of maternal deaths globally.
Atenolol has been associated with intrauterine growth retardation, as well as decreased placental growth and weight when prescribed during pregnancy. ACEis and ARBs are contraindicated in women who are or who intend to become pregnant. [47] Periodontal disease could mitigate the efficacy of antihypertensive drugs. [68] Race.
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Antihypertensive drug use during pregnancy is relatively common and increasing. [32] Only a small proportion of available antihypertensive drugs have been tested in pregnant women, and many are contraindicated. [citation needed] It is important to make the exposure of medications to the baby as small as possible. [30]
Azilsartan must not be used with aliskiren, a renin inhibitor, in patients with diabetes as this increases the risk of serious adverse effects. [5] [2] Like other antihypertensive drugs acting on the renin–angiotensin system, it is contraindicated during the second and third trimesters of pregnancy.
Use during pregnancy may harm the baby. [2] The combination was approved for medical use in the United States in 1989. [3] It is on the World Health Organization's List of Essential Medicines. [5] It is available as a generic medication. [4]
Aliskiren (brand names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors.It is used for essential (primary) hypertension. [2] While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit.
Use in pregnancy may harm the baby and use when breastfeeding is not recommended. [10] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II. [5] Irbesartan was patented in 1990, and approved for medical use in 1997. [11] It is available as a generic medication. [9]
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