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RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. [11] It consists of RNA polymerase II, a subset of general transcription factors , and regulatory proteins known as SRB proteins.
[5] [6] The core RNA polymerase complex forms a "crab claw" or "clamp-jaw" structure with an internal channel running along the full length. [7] Eukaryotic and archaeal RNA polymerases have a similar core structure and work in a similar manner, although they have many extra subunits.
RNA polymerase III (Pol III) transcribes small non-coding RNAs, including tRNAs, 5S rRNA, U6 snRNA, SRP RNA, and other stable short RNAs such as ribonuclease P RNA. [7] Structure of eukaryotic RNA polymerase II (light blue) in complex with α-amanitin (red), a strong poison found in death cap mushrooms that targets this vital enzyme
229906 Ensembl ENSG00000137947 ENSMUSG00000028271 UniProt Q00403 P62915 RefSeq (mRNA) NM_001514 NM_145546 RefSeq (protein) NP_001505 NP_663521 Location (UCSC) Chr 1: 88.85 – 88.89 Mb Chr 3: 142.47 – 142.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II ...
Transcription preinitiation complex, represented by the central cluster of proteins, causes RNA polymerase to bind to target DNA site. The PIC is able to bind both the promoter sequence near the gene to be transcribed and an enhancer sequence in a different part of the genome, allowing enhancer sequences to regulate a gene distant from it.
RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. [ 1 ] [ 2 ] It consists of RNA polymerase II , a subset of general transcription factors , and regulatory proteins known as SRB proteins [ clarification needed ] .
Sequence 2 is then free to hybridize with sequence 3 to form the 2–3 structure, which then prevents the formation of the 3–4 termination hairpin, which is why the 2–3 structure is called an anti-termination hairpin. In the presence of the 2–3 structure, RNA polymerase is free to continue transcribing the operon.
5430 20020 Ensembl ENSG00000284832 ENSG00000181222 ENSMUSG00000005198 UniProt P24928 P08775 RefSeq (mRNA) NM_000937 NM_009089 NM_001291068 RefSeq (protein) NP_000928 NP_001277997 Location (UCSC) Chr 17: 7.48 – 7.51 Mb Chr 11: 69.62 – 69.65 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded ...