Search results
Results from the WOW.Com Content Network
The broad range of ligands that bind to the ER can create a spectrum of ER complexes that are fully estrogenic or antiestrogenic at a specific target site. [ 3 ] [ 4 ] [ 22 ] The main result of a ligand-binding to ER is a structural rearrangement of the ligand- binding pocket , primarily in the AF-2 of the C-terminal region.
There are two different forms of the estrogen receptor, usually referred to as α and β, each encoded by a separate gene (ESR1 and ESR2, respectively).Hormone-activated estrogen receptors form dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα (αα) or ERβ (ββ) homodimers or ERαβ (αβ) heterodimers. [3]
Sivifene (A-007) was initially thought to be a SERM due to its structural similarity to tamoxifen but it was subsequently found not to bind to the estrogen receptor (ER). [8] Tesmilifene (DPPE; YMB-1002, BMS-217380-01) is also structurally related to tamoxifen but similarly does not bind to the ER and is not a SERM.
A selective estrogen receptor degrader or downregulator (SERD) is a type of drug that selectively binds to the estrogen receptor (ER) and induces its degradation, and thus causes its downregulation. [1]
In a symbolic gesture of this transference, he was told by Mark Greene "you set the tone" on Dr. Greene's last day in the ER. Dr. Greene had been told the same thing, by Dr. Morgenstern, in the pilot episode in season 1 of the show. Dr. Carter, in turn, said the same thing to Dr. Archie Morris as Carter left the ER, although Morris did not ...
After translation, proteins within the ER make sure that the protein is folded correctly. If after a first attempt the folding is unsuccessful, a second folding is attempted. If this fails too the protein is exported to the cytosol and labelled for destruction. Aside from the folding, there is also a sugar chain added to the protein.
An Evening with Belafonte/Makeba is a Grammy Award-winning 1965 album by Harry Belafonte and Miriam Makeba, released by RCA Victor.It was the second outcome of the long lasting collaboration between Belafonte and Makeba, the first being the appearance of Makeba in the song "One More Dance" on Belafonte's 1960 album, Belafonte Returns to Carnegie Hall.
Representational difference analysis (RDA) is a technique used in biological research to find sequence differences in two genomic or cDNA samples. Genomes or cDNA sequences from two samples (i.e. cancer sample and a normal sample) are PCR amplified and differences analyzed using subtractive DNA hybridization.