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Symptoms start two hours to five days after exposure. [3] Cholera is caused by a number of types of Vibrio cholerae, with some types producing more severe disease than others. [2] It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. [2] Undercooked shellfish is a common source. [9]
Cholera is a bacterial infection of the intestines that leads to severe diarrhea and rapid dehydration, "which can quickly become life-threatening without treatment," says Dr. Jason Nagata, a ...
Symptoms of Cholera include nausea, diarrhea, and vomiting which contribute to dehydration, erratic heartbeat, and shriveled skin. [84] These symptoms contributed to Cholera's high mortality rate. [85] Some of the most significant Cholera outbreaks occurred during the 1800s (when the cause was still unknown).
Although Koch was convinced that the bacterium was the cholera pathogen, he could not entirely procure critical evidence that the bacterium produced the symptoms in healthy subjects (an important element in what was later known as Koch's postulates). His experiment on animals using his pure bacteria culture did not lead to the appearance of the ...
The study of cholera in England by John Snow, between 1849 and 1854, led to significant advances in the field of epidemiology. [ 4 ] [ 10 ] Seven large outbreaks have occurred over the last 200 years, with millions of deaths.
Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is an AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae. [ 1 ] [ 2 ] CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. [ 3 ]
The Broad Street cholera outbreak (or Golden Square outbreak) was a severe outbreak of cholera that occurred in 1854 near Broad Street (now Broadwick Street) in Soho, London, England, during the worldwide 1846–1860 cholera pandemic.
Symptoms of the disease appear between 12 hours and 5 days of infection; however, only 10% of infected people show severe symptoms of watery diarrhoea, vomiting and leg cramps. [8] Cholera is diagnosed through a stool test or rectal swab, and today treatment takes the form of an oral rehydration solution (ORS).