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A Coulter counter [1] [2] is an apparatus for counting and sizing particles suspended in electrolytes. The Coulter counter is the commercial term for the technique known as resistive pulse sensing or electrical zone sensing. The apparatus is based on the Coulter principle named after its inventor, Wallace H. Coulter.
Wallace H. Coulter (February 17, 1913 – August 7, 1998) was an American electrical engineer, inventor, and businessman. The best known of his 85 patents is the Coulter principle , which provides a method for counting and sizing microscopic particles suspended in fluid.
The Coulter Counter was created by Wallace H. Coulter in 1949. The Coulter counter consists of two electrolyte reservoirs that are connected by a small channel, through which a current of ions flow. Each particle drawn through the channel causes a brief change to the electrical resistance of the liquid.
Scientific advances demonstrating these capabilities have been published in the scientific literature, such as by Kasianowicz et al., [4] Saleh and Sohn, [5] and Fraikin et al. [6] These together illustrate a variety of methods to fabricate microfluidic or lab-on-a-chip versions of the Coulter counter technology.
The first automated hematology analyzer, the Coulter counter, was invented in the early 1950s by Wallace H. Coulter. [ 93 ] [ 94 ] The analyzer worked on the Coulter principle, which states that when cells are suspended in a fluid carrying an electric current and passed through an aperture, they cause decreases in current proportional to their ...
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