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Flowchart showing baroreceptor reflex. The baroreflex or baroreceptor reflex is one of the body's homeostatic mechanisms that helps to maintain blood pressure at nearly constant levels. The baroreflex provides a rapid negative feedback loop in which an elevated blood pressure causes the heart rate to decrease. Decreased blood pressure decreases ...
Some biological systems exhibit negative feedback such as the baroreflex in blood pressure regulation and erythropoiesis. Many biological processes (e.g., in the human anatomy) use negative feedback. Examples of this are numerous, from the regulating of body temperature, to the regulating of blood glucose levels.
Baroreceptor. Baroreceptors (or archaically, pressoreceptors) are sensors located in the carotid sinus (at the bifurcation of common carotid artery into external and internal carotids) and in the aortic arch. [1] They sense the blood pressure and relay the information to the brain, so that a proper blood pressure can be maintained.
35094-2. Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" refers to the pressure in a brachial artery, where it is most commonly measured.
However, the human body exhibits a wide range of resting blood pressure numbers with no correction throughout the day depending on the environment, such as low pressures during sleep and higher pressures in the morning. [6] Animal studies have also shown non-homeostatic patterns in times of arousal (or stress). The body elevates blood pressure ...
In response to a lowering of the plasma sodium concentration, or to a fall in the arterial blood pressure, the juxtaglomerular cells release renin into the blood. [ 64 ] [ 65 ] [ 66 ] Renin is an enzyme which cleaves a decapeptide (a short protein chain, 10 amino acids long) from a plasma α-2-globulin called angiotensinogen .
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the G i heterotrimeric G-protein. It consists of three highly homologous subtypes, including α 2A -, α 2B -, and α 2C -adrenergic. Some species other than humans express a fourth α 2D -adrenergic receptor as well. [1]
An increase in sensed pressure results in an increased rate of firing by the baroreceptors and a negative feedback response, lowering systemic arterial pressure. Aldosterone release causes sodium and water retention, which causes increased blood volume, and a subsequent increase in blood pressure, which is sensed by the baroreceptors. [39]
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